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Virtual Seminar: Dr Serena Nik-Zainal, CRUK Advanced Clinician Scientist and Honorary Consultant in Clinical Genetics at Cambridge


Join us Wednesday 20th October at 13.30 for an online seminar titled, 'Harnessing the value of whole genome sequencing in human cancers'

Date: Tuesday 20 October 2020

Time: 13.30-14.30

Place: Zoom https://us02web.zoom.us/j/86957509182?pwd=QWxsRHlGTUl3VGZJWCtnWGNMSHVQZz09


Abstract: Mutational signatures are the imprints of DNA damage and DNA repair processes that have been operative during tumorigenesis. They are biologically informative, reporting on the processes that have contributed to the developmental history of each patient’s cancer. In this lecture, on behalf of my team and my collaborators, I shall provide an update on the field, focusing on validation of these abstract mathematical concepts, untangling the mechanisms underpinning mutation patterns in human somatic cells, and describing the new insights that we have gained through combinations of computational analysis and experiments in cell-based systems. We showcase how mutational-signature-based clinical algorithms have been developed, describe the path taken in translating these towards medical utility and for balance, highlight some of the hurdles that need to be navigated in this type of translational research.

Biography: Serena is a CRUK Advanced Clinician Scientist and Honorary Consultant in Clinical Genetics in Cambridge, UK. Serena went to the UK as a PETRONAS scholar from Malaysia in 1993, obtaining a First in Physiology at University of Cambridge before completing her medical degree in 2000. She trained as a physician and specialized in Clinical Genetics. She undertook a PhD at the Wellcome Sanger Institute in 2009 pioneering exploration of breast cancers through whole genome sequencing (WGS).

Advice to all Participants

  • Before joining test your audio/video connection and settings after loading Zoom.
  • To prevent WiFi dropouts and speed issues connect via a wired ethernet, where possible.
  • If connecting from a laptop, plug in the charger as battery (only) use can adversely affect video quality.
  • Please be aware this is a video conference, people can see and hear you unless video and/or audio is muted. Familiarise yourself with turning audio and video capability on and off. Good virtual conference etiquette is to keep the audio muted when not speaking.
  • To avoid audio feedback and/or echo use earbuds/headphones.
  • Be aware of your surroundings and how you appear visually. Wear neutral, solid-coloured clothing. Avoid black, white, or striped clothing. Close blinds/curtains on windows so that you are easier to see on video.
  • Any joining issues please contact the research.office@earlham.ac.uk

For the Q&A session – to ask a question please type it into the chat box and wait to be prompted by the session chair.

For further information, please contact Eva.