Dr Rianne Lord
Lecturer in Inorganic Chemistry
Rianne’s research focuses on the synthesis and design of new metal-based therapeutics, working on compound modification and structure activity relationships. She is conducting in vitro analysis of all new compounds against a range of cancerous and normal cell lines, including assays on cellular interactions, uptake and compound speciation in physiological conditions. Her recent work has highlighted several classes of metal-based compounds which have high activity and cancer cell selectivity against colorectal cancer and lung cancer, and she is currently working on understanding the compounds’ modes of action within these cancers.
Rianne is a new member of staff at UEA and is in the process of building her research group, and moving forward, the group will be focused on the development of 3D cell cultures and cancer stem cell models. The research will also move towards the study of personalised medicine for colorectal cancer. In particular, the group will be assessing the hypoxic nature of the cancers and working on fine-tuning the metal compounds’ oxidation states to enable them to “switch on” their activity when in hypoxic environments.