Dr Iain Macaulay
Our group develops tools to analyse the genomes, epigenomes and transcriptomes of individual cells, focusing especially on multi-omics approaches, where multiple aspects of cellular omics can be profiled in parallel.
We are particularly interested in the application of these techniques to understand alternative splicing in normal cell development and disease, including the consequences of splicing mutations and fusion transcripts in cancer.
We have expertise in a wide range of genomics approaches and platform for single-cell isolation. We have two cell sorters (BD FACS Melody, BD Aria Fusion), a Leica LMD7 Laser Microdissection platform and a Cellenion Cellenone platform for cell isolation. We also have a 10X Genomics Chromium instrument for high-throughput single-cell analysis, and through the Earlham Institute’s Genomics Pipelines, access to cutting edge short- and long-read sequencing platforms (Illumina/PacBio/Nanopore).
Funders: BBSRC, Wellcome Trust, CRUK